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Publications

2024

Discovery of dual-active ethionamide boosters inhibiting the Mycobacterium tuberculosis ESX-1 secretion system

The AMR Accelerator: from individual organizations to efficient antibiotic development partnerships

A systematic review of economic evaluations of pharmacological treatments for active tuberculosis

Evaluation of critical parameters in the hollow‐fibre system for tuberculosis: A case study of moxifloxacin

2023

Implementing best practises on data generation and reporting of Mycobacterium tuberculosis time kill assays: a case study of standardized protocol within the ERA4TB consortium

Uptake-independent killing of macrophages by extracellular aggregates of Mycobacterium tuberculosis is ESX-1 and PDIM-dependent

Mechanopathology of biofilm-like Mycobacterium tuberculosis cords

Characterization of Two Novel Inhibitors of the Mycobacterium tuberculosis Cytochrome bc1 Complex

Academia and industry agreement on a feasibility tool for first‐time‐in‐human clinical trial units

Implementing best practices on data generation and reporting of Mycobacterium tuberculosis in vitro assays within the ERA4TB consortium

2022

Computer-Aided diagnostic for classifying Chest X-Ray Images Using Deep Ensemble Learning

RNase E and HupB dynamics foster mycobacterial cell homeostasis and fitness

Microfluidic dose–response platform to track the dynamics of drug response in single mycobacterial cells

2021

The contribution of microfluidics to the fight against tuberculosis

2020

Development of an Inverted Epifluorescence Microscope for Long-Term Monitoring of Bacteria in Multiplexed Microfluidic Devices

Tolerance and Persistence to Drugs: A Main Challenge in the Fight Against Mycobacterium tuberculosis

Deliverables

D1.12 Second Report on clinical and preclinical datasets standardized and integrated into the DDIM

D4.2 Implementation of PK/PD MALDI-MS imaging to analyses infected tissue

D2.1. Implementation of HFS-TB in a BSL3 setting in Europe

D1.10 First Report on clinical and preclinical datasets standardized and integrated into the DDIM

D1.3 Instantiation of EU-based Drug Development Information Management (DDIM) system

D1.4 Initial standardized data templates for collection and reporting of clinical and preclinical data available to Consortium members

D1.8 Standardized templates for collection and reporting of clinical and preclinical data available to consortium members –Interim reportD1.6 Availability of existing preclinical and clinical TB datasets – Interim Report

D1.6 Availability of existing preclinical and clinical TB datasets – Interim Report

D3.1 First Report on implementation of selected mouse models for in vivo evaluation of drug candidates

D8.1 Project Handbook

D8.4 Project Communication Plan

Know how accelerate the development of new treatment regimens for tuberculosis, discover our project

The Project